Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
[HTML][HTML] Telomere-specific regulation of TERRA and its impact on telomere stability
J Rivosecchi, K Jurikova, E Cusanelli - Seminars in Cell & Developmental …, 2024 - Elsevier
TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation
M Turner, YM Danino, M Barshai… - Nucleic acids …, 2022 - academic.oup.com
RNA G-quadruplexes (rG4s) are RNA secondary structures, which are formed by guanine-
rich sequences and have important cellular functions. Existing computational tools for rG4 …
rich sequences and have important cellular functions. Existing computational tools for rG4 …
BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
YM Danino, L Molitor… - Nucleic Acids …, 2023 - academic.oup.com
Bloom's syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA
secondary structures such as G-quadruplexes (G4s). However, its role in the regulation of …
secondary structures such as G-quadruplexes (G4s). However, its role in the regulation of …
RNA G-quadruplexes and stress: emerging mechanisms and functions
RNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich
sequences that are found in different regions of RNA molecules. These structures have been …
sequences that are found in different regions of RNA molecules. These structures have been …
Small RNA structural biochemistry in a post-sequencing era
High-throughput sequencing has had an enormous impact on small RNA research during
the past decade. However, sequencing only offers a one-dimensional view of the …
the past decade. However, sequencing only offers a one-dimensional view of the …
Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role
Nuclear localization of the metabolic enzyme PKM2 is widely observed in various cancer
types. We identify nuclear PKM2 as a non-canonical RNA-binding protein (RBP) that …
types. We identify nuclear PKM2 as a non-canonical RNA-binding protein (RBP) that …
G-quadruplexes rescuing protein folding
Maintaining the health of the proteome is a critical cellular task. Recently, we found G-
quadruplex (G4) nucleic acids are especially potent at preventing protein aggregation in …
quadruplex (G4) nucleic acids are especially potent at preventing protein aggregation in …
RNA G-quadruplex in functional regulation of noncoding RNA: Challenges and emerging opportunities
VJ Sahayasheela, H Sugiyama - Cell Chemical Biology, 2024 - cell.com
Summary G-quadruplexes (G4s) are stable, noncanonical structures formed in guanine (G)-
rich sequences of DNA/RNA. G4 structures are reported to play a regulatory role in various …
rich sequences of DNA/RNA. G4 structures are reported to play a regulatory role in various …
Emerging roles for G‐quadruplexes in proteostasis
How nucleic acids interact with proteins, and how they affect protein folding, aggregation,
and misfolding is a still‐evolving area of research. Considerable effort is now focusing on a …
and misfolding is a still‐evolving area of research. Considerable effort is now focusing on a …