Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor …

In chronic obstructive pulmonary disease (COPD), exacerbations are generally associated
with several causes, including pollutants, viruses, bacteria that are responsible for an excess …

Organotypic cultures of primary human airway epithelial cells have been used to investigate
the morphology, ion and fluid transport, innate immunity, transcytosis, infection …

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …

Epiregulin is a 46-amino acid protein that belongs to the epidermal growth factor (EGF)
family of peptide hormones. Epiregulin binds to the EGF receptor (EGFR/ErbB1) and ErbB4 …

Background Bronchiolisation of distal airspaces is an unexplained feature of idiopathic
pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the …

In this review article, we will first provide a brief overview of the ErbB receptor–ligand system
and its importance in developmental and physiological processes. We will then review the …

Chronic respiratory diseases, including pulmonary fibrosis, chronic obstructive pulmonary
disease (COPD) and lung cancer, are the second leading cause of death among …

Airway epithelium plays an important role as the first barrier from external pathogens,
including bacteria, viruses, chemical substances, and allergic components. Airway epithelial …

Cystic fibrosis is caused by genetic defects that impair the CFTR channel in airway epithelial
cells. These defects may be overcome by specific CFTR modulating drugs, for which the …