Antimicrobial and immunomodulatory properties and applications of marine-derived proteins and peptides

HK Kang, HH Lee, CH Seo, Y Park - Marine Drugs, 2019 - mdpi.com
Marine organisms provide an abundant source of potential medicines. Many of the marine-
derived biomaterials have been shown to act as different mechanisms in immune …

Protein-based adjuvants for vaccines as immunomodulators of the innate and adaptive immune response: Current knowledge, challenges, and future opportunities

DA Díaz-Dinamarca, ML Salazar, BN Castillo… - Pharmaceutics, 2022 - mdpi.com
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …

Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients

D Reyes, L Salazar, E Espinoza, C Pereda… - British journal of …, 2013 - nature.com
Background: Recently, we produced a tumour antigen-presenting cells (TAPCells) vaccine
using a melanoma cell lysate, called TRIMEL, as an antigen source and an activation factor …

A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma

S Arancibia, C Espinoza, F Salazar, M Del Campo… - PloS one, 2014 - journals.plos.org
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as
immunomodulatory proteins with proven anti-cancer properties. The biodiversity of …

[HTML][HTML] Hemocyanins stimulate innate immunity by inducing different temporal patterns of proinflammatory cytokine expression in macrophages

TY Zhong, S Arancibia, R Born, R Tampe… - The Journal of …, 2016 - journals.aai.org
Hemocyanins induce a potent Th1-dominant immune response with beneficial clinical
outcomes when used as a carrier/adjuvant in vaccines and nonspecific immunostimulant in …

Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non‐specific immunostimulatory effects

S Arancibia, MD Campo, E Nova… - European journal of …, 2012 - Wiley Online Library
Hemocyanins, which boost the immune system of mammals, have been used as carrier‐
adjuvants to promote Ab production against haptens and peptides, as immunostimulants …

Mollusk hemocyanins as natural immunostimulants in biomedical applications

MI Becker, S Arancibia, F Salazar… - Immune response …, 2014 - books.google.com
Hemocyanins, the massive oxygen-transporting glycoproteins found freely dissolved in the
hemolymph of some mollusks, are potent natural immunostimulants when inoculated in …

Litopenaeus vannamei hemocyanin exhibits antitumor activity in S180 mouse model in vivo

S Liu, L Zheng, JJ Aweya, Z Zheng, M Zhong, J Chen… - Plos one, 2017 - journals.plos.org
Hemocyanin is a multifunctional glycoprotein, which also plays multiple roles in immune
defense. While it has been demonstrated that hemocyanin from some mollusks can induce …

N-glycan structures of β-HlH subunit of Helix lucorum hemocyanin

L Velkova, P Dolashka, J Van Beeumen… - Carbohydrate …, 2017 - Elsevier
The carbohydrate structures of molluscan hemocyanins have recently received particular
interest due to their specific monosaccharide composition, as well as their …

Antitumour activity of Helix hemocyanin against bladder carcinoma permanent cell lines

A Dolashki, P Dolashka, A Stenzl… - Biotechnology & …, 2019 - Taylor & Francis
Hemocyanins are oxygen-transporting glycoproteins in molluscs and arthropods. In this
study, we assayed the biomacromolecules from the molluscs Helix lucorum (HlH), Rapana …