Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Since the first dendrimer was reported in 1978 by Fritz Vögtle, dendrimer research has
grown exponentially, from synthesis to application in the past four decades. The distinct …

Abstract The concept of 1, 3‐dipolar cycloadditions was presented by Rolf Huisgen 60 years
ago. Previously unknown reactive intermediates, for example azomethine ylides, were …

Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

Dendrimers are novel polymeric nanoarchitectures characterized by hyper-branched 3D-
structure having multiple functional groups on the surface that increases their functionality …

Designing therapeutics is a process with many challenges. Even if the first hurdle—
designing a drug that modulates the action of a particular biological target in vitro—is …

This review is focused on the mechanistic aspects and recent trends of the metal-catalyzed
azide-alkyne cycloaddition (MAAC) so-called “click” reactions with catalysts based on …