Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of
immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and …

Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

Millions of people around the world suffer from psychiatric illnesses, causing unbearable
burden and immense distress to patients and their families. Accumulating evidence …

Major depressive disorder (MDD) or Depression is one of the serious neuropsychiatric
disorders affecting over 280 million people worldwide. It is 4th important cause of disability …

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …

Single-particle cryogenic electron microscopy (cryo-EM) has been elevated to the
mainstream of structural biology propelled by technological advancements in numerous …

Mitochondria are the prime source of cellular energy, and are also responsible for important
processes such as oxidative stress, apoptosis and Ca2+ homeostasis. Depression is a …

Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator that is highly abundant
in the brain. It binds to methylated genomic DNA to regulate a range of physiological …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …