The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes
including cell proliferation, differentiation and DNA repair. Changes in these pathways can …

DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form
interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA …

The hematopoietic system is susceptible to ionizing radiation (IR), which can cause acute
hematopoietic failure or long-term myelosuppression. As the most primitive cells of the …

Ovarian cancer is the most lethal gynecologic malignancy. Poly (ADP-ribose) polymerase
inhibitors (PARPi) are effective in treating ovarian cancer. However, cancer cell insensitivity …

Stalled DNA replication fork restart after stress as orchestrated by ATR kinase, BLM
helicase, and structure-specific nucleases enables replication, cell survival, and genome …

Wnt signaling maintains diverse adult stem cell compartments and is implicated in
chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven …

Replication stress, a major cause of genome instability in cycling cells, is mainly prevented
by the ATR‐dependent replication stress response pathway in somatic cells. However, the …

Mesenchymal stem cells (MSCs) are multipotent adult stem cells present in virtually all
tissues; they have potent self-renewal capacity and differentiate into multiple cell types. For …

Background Tumor metastasis is the main cause of death of cancer patients, and cancer
stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the …

The transcription factor MYBL2 is widely expressed in proliferating cells. Aberrant
expression of MYBL2 contributes to tumor malignancy and is associated with poor patient …