Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
Computer simulations of protein–membrane systems
The interactions between proteins and membranes play critical roles in signal transduction,
cell motility, and transport, and they are involved in many types of diseases. Molecular …
cell motility, and transport, and they are involved in many types of diseases. Molecular …
[HTML][HTML] Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges
O Press-Sandler, Y Miller - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes
(T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in …
(T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in …
[HTML][HTML] Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils
The amyloid deposits of human islet amyloid polypeptide (hIAPP) are found in type 2
diabetes patients. hIAPP monomer is intrinsically disordered in solution, whereas it can form …
diabetes patients. hIAPP monomer is intrinsically disordered in solution, whereas it can form …
Interplay between membrane composition and structural stability of membrane-bound hIAPP
Amyloid aggregates are characteristic of many serious diseases such as Alzheimer's
disease, Parkinson's, and type 2 diabetes and commonly involve intrinsically disordered …
disease, Parkinson's, and type 2 diabetes and commonly involve intrinsically disordered …
Molecular Insights into Distinct Membrane-insertion Behaviors and Mechanisms of 20 Amino Acids: an All-atom MD Simulation Study
W Tu, X Dong, L Ou, X Zhang, B Yuan… - Chemical Research in …, 2023 - Springer
I nterfacial interactions of proteins with cell membranes play important roles in fundamental
physiological processes of cells. The binding of proteins to membranes involves interactions …
physiological processes of cells. The binding of proteins to membranes involves interactions …
Molecular basis of the anchoring and stabilization of human islet amyloid polypeptide in lipid hydroperoxidized bilayers
YR Espinosa, DIB Valderrama, CM Carlevaro… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The molecular structure of membrane lipids is formed by mono-or polyunsaturations on their
aliphatic tails that make them susceptible to oxidation, facilitating the incorporation of …
aliphatic tails that make them susceptible to oxidation, facilitating the incorporation of …
Coexisting Ordered and Disordered Membrane Phases Have Distinct Modes of Interaction with Disease-Associated Oligomers
Ordered membrane domains are thought to influence the attachment and insertion of toxic
amyloid oligomers, and consequently, their toxicity. However, if and how the molecular …
amyloid oligomers, and consequently, their toxicity. However, if and how the molecular …
Formation of α-helical and β-sheet Structures in Membrane-Bound Human IAPP Monomer and the Resulting Membrane Deformation
The amyloid formation of human islet amyloid polypeptide (hIAPP)—an intrinsically
disordered peptide, is associated with type II diabetes. Cellular membranes, especially …
disordered peptide, is associated with type II diabetes. Cellular membranes, especially …