HIV: cell binding and entry
The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …
Structure and function of respiratory syncytial virus surface glycoproteins
JS McLellan, WC Ray, ME Peeples - Challenges and opportunities for …, 2013 - Springer
The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the
attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of …
attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of …
The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex
Coronavirus entry is mediated by the viral spike (S) glycoprotein. The 180-kDa oligomeric S
protein of the murine coronavirus mouse hepatitis virus strain A59 is posttranslationally …
protein of the murine coronavirus mouse hepatitis virus strain A59 is posttranslationally …
Core structure of gp41 from the HIV envelope glycoprotein
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a
complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell …
complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell …
The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens
R Wyatt, J Sodroski - Science, 1998 - science.org
The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
X Wei, JM Decker, H Liu, Z Zhang… - Antimicrobial agents …, 2002 - Am Soc Microbiol
The synthetic peptide T-20 (enfuvirtide) represents the first of a new class of antiretroviral
compounds to demonstrate in vivo potency by targeting a step in viral entry. T-20 inhibits a …
compounds to demonstrate in vivo potency by targeting a step in viral entry. T-20 inhibits a …
Atomic structure of the ectodomain from HIV-1 gp41
W Weissenhorn, A Dessen, SC Harrison, JJ Skehel… - Nature, 1997 - nature.com
Fusion of viral and cellular membranes by the envelope glyco-protein gp120/gp41 effects
entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 …
entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 …
Mechanisms of viral membrane fusion and its inhibition
DM Eckert, PS Kim - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract Viral envelope glycoproteins promote viral infection by mediating the fusion of the
viral membrane with the host-cell membrane. Structural and biochemical studies of two viral …
viral membrane with the host-cell membrane. Structural and biochemical studies of two viral …
Pathogenesis of human immunodeficiency virus infection
JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …
number of different cells in the body and escaping the host immune response against it. HIV …
Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of …
S Liu, G Xiao, Y Chen, Y He, J Niu, CR Escalante… - The Lancet, 2004 - thelancet.com
Background Studies on the fusion-inhibitory peptides derived from the heptad repeat 1 and
2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial …
2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial …