Antitumoral activity of snake venom proteins: new trends in cancer therapy

LA Calderon, JC Sobrinho, KD Zaqueo… - BioMed research …, 2014 - Wiley Online Library
For more than half a century, cytotoxic agents have been investigated as a possible
treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues …

[HTML][HTML] Venom-based peptide therapy: Insights into anti-cancer mechanism

R Ma, R Mahadevappa, HF Kwok - Oncotarget, 2017 - ncbi.nlm.nih.gov
The 5-year relative survival rate of all types of cancer has increased significantly over the
past three decades partly due to the targeted therapy. However, still there are many targeted …

[PDF][PDF] Venoms classification and therapeutic uses: a narrative review.

MA Morsy, S Gupta, CP Dora, V Jhawat… - European Review for …, 2023 - europeanreview.org
The mere glimpse of venomous animals has always terrified humans because of the
devastating effects of their venoms. However, researchers across the globe have isolated …

Anticancer activity of toxins from bee and snake venom—An overview on ovarian cancer

MA Moga, OG Dimienescu, CA Arvătescu, P Ifteni… - Molecules, 2018 - mdpi.com
Cancer represents the disease of the millennium, a major problem in public health. The
proliferation of tumor cells, angiogenesis, and the relationship between the cancer cells and …

[HTML][HTML] Purification of a lectin with antibacterial activity from Bothrops leucurus snake venom

E dos Santos Nunes, MAA De Souza… - … and Physiology Part B …, 2011 - Elsevier
A novel lectin was isolated from Bothrops leucurus snake venom using a combination of
affinity and gel filtration chromatographies. The lectin (BlL) agglutinated glutaraldehyde …

Snake venom, a potential treatment for melanoma. a systematic review

TS Bialves, CLQB Junior, MF Cordeiro… - International Journal of …, 2023 - Elsevier
Despite advances in treating patients with melanoma, there are still many treatment
challenges to overcome. Studies with snake venom-derived proteins/peptides describe their …

Animal venoms have potential to treat cancer

B Chatterjee - Current topics in medicinal chemistry, 2018 - ingentaconnect.com
The resistance to chemotherapeutics by the cancerous cells has made its treatment more
complicated. Animal venoms have emerged as an alternative strategy for anti-cancer …

[PDF][PDF] Pathophysiological and pharmacological effects of snake venom components: molecular targets

L Fatima, C Fatah - J Clin Toxicol, 2014 - researchgate.net
Snake venoms are a mixture of hydrolases which produce complex pathogenesis such as
bleeding, dermo/myonecrosis, inflammation and coagulation disorders. The toxicity of …

Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms

C Araya, B Lomonte - Cell biology international, 2007 - Wiley Online Library
The effects of two cationic synthetic peptides, derived from the C‐terminal region of Lys49
phospholipase A2 homologues from snake venoms, upon various murine tumor cell lines …

[HTML][HTML] Cytotoxic effect and apoptosis induction by Bothrops leucurus venom lectin on tumor cell lines

ES Nunes, MAA Souza, AFM Vaz, TG Silva, JS Aguiar… - Toxicon, 2012 - Elsevier
Neoplastic transformation is the abnormal proliferation of cells. These transformations are
often related to changes in cell surface glycoconjugates which can be detected by lectins …