Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases

S Ashique, G De Rubis, E Sirohi, N Mishra… - Chemico-biological …, 2022 - Elsevier
The human microbiota is fundamental to correct immune system development and balance.
Dysbiosis, or microbial content alteration in the gut and respiratory tract, is associated with …

IL-17 cytokines and chronic lung diseases

F Ritzmann, LP Lunding, R Bals, M Wegmann… - Cells, 2022 - mdpi.com
IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …

Attenuation of cigarette-smoke-induced oxidative stress, senescence, and inflammation by berberine-loaded liquid crystalline nanoparticles: in vitro study in 16HBE …

KR Paudel, N Panth, B Manandhar, SK Singh, G Gupta… - Antioxidants, 2022 - mdpi.com
Cigarette smoke is considered a primary risk factor for chronic obstructive pulmonary
disease. Numerous toxicants present in cigarette smoke are known to induce oxidative …

Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

Microbiome as an immune regulator in health, disease, and therapeutics

VM Juarez, AN Montalbine, A Singh - Advanced drug delivery reviews, 2022 - Elsevier
New discoveries in drugs and drug delivery systems are focused on identifying and
delivering a pharmacologically effective agent, potentially targeting a specific molecular …

Rediscovering the therapeutic potential of agarwood in the management of chronic inflammatory diseases

JMR Alamil, KR Paudel, Y Chan, D Xenaki… - Molecules, 2022 - mdpi.com
The inflammatory response is a central aspect of the human immune system that acts as a
defense mechanism to protect the body against infections and injuries. A dysregulated …

[HTML][HTML] Lung microbial-host interface through the lens of multi-omics

S Singh, JG Natalini, LN Segal - Mucosal immunology, 2022 - Elsevier
In recent years, our understanding of the microbial world within us has been revolutionized
by the use of culture-independent techniques. The use of multi-omic approaches can now …

Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease

A Kayongo, NM Robertson, T Siddharthan… - Frontiers in …, 2023 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global
mortality, with three million deaths reported annually. This impact is expected to increase …

Nutraceuticals: Unlocking newer paradigms in the mitigation of inflammatory lung diseases

Y Chan, VSR Raju Allam, KR Paudel… - Critical reviews in …, 2023 - Taylor & Francis
Persistent respiratory tract inflammation contributes to the pathogenesis of various chronic
respiratory diseases, such as asthma, chronic obstructive pulmonary disease, and …