Pulmonary immune homeostasis is maintained by a network of tissue-resident cells that
continually monitor the external environment, and in health, instruct tolerance to innocuous …

Although we might shudder at the thought of billions of bacteria living in our lower intestine,
we are colonized by these passengers shortly after birth. However, the relationship is mostly …

Allergic atopic disorders, such as rhinitis, asthma, and atopic dermatitis, are the result of a
systemic inflammatory reaction triggered by type 2 T helper (Th2) cell‐mediated immune …

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper
T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s …

The respiratory tract is characterized by an extensive surface area that is in direct contact
with the environment, posing a significant problem for effective immune surveillance. Yet …

Innate recognition of invading pathogens in peripheral tissues results in the recruitment of
circulating memory CD8+ T cells to sites of localized inflammation during the early phase of …

Experimental autoimmune myocarditis (EAM) appears after infectious heart disease, the
most common cause of dilated cardiomyopathy in humans. Here we report that mice lacking …

T cell responses are essential for appropriate protection against pathogens. T cell immunity
is achieved through the ability to discriminate between foreign and self-molecules, and this …

Chronic obstructive pulmonary disease (COPD) progression is characterized by
accumulation of inflammatory mucous exudates in the lumens of small airways, and …

The range of regulatory T cell (TR cell) types that control immune responses is poorly
understood. We describe here a population of TR cells that developed in vivo from naive …