Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-
associated tau protein characterizes 80% of all dementia disorders, the most common …

Introduction This study investigated the diagnostic and disease‐monitoring potential of
plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) …

Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …

Tauopathy is a hallmark pathology of Alzheimer's disease with a strong relationship with
cognitive impairment. As such, understanding tau may be a key to clinical interventions. In …

The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its
relationship with tauopathy is less established. We investigated the relationship between …

Clinical trials with anti-tau drugs will need to target individuals at risk of accumulating tau.
Our objective was to identify variables available in a research setting that predict future rates …

Background Amyloid-β (Aβ) likely plays a primary role in Alzheimer's disease pathogenesis,
but longitudinal Aβ, tau, and neurodegeneration (A/T/N) measurements in the same …

A recurring debate concerns whether regions of primate prefrontal cortex (PFC) support
domain-flexible or domain-specific processes. Here we tested the hypothesis with functional …

Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing
evidence show that sensory dysfunctions are one of the early signs diagnosing the …