Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

Rationale: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The
NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

The follicle is the functional unit of the ovary, which is composed of three types of cells:
oocytes, granulosa cells, and theca cells. Ovarian follicle development and the subsequent …