Spike protein of SARS-CoV-2 variants: a brief review and practical implications

KL Candido, CR Eich, LO de Fariña… - Brazilian Journal of …, 2022 - Springer
The scientific community has been alarmed by the possible immunological evasion, higher
infectivity, and severity of disease caused by the newest variants of SARS-CoV-2. The spike …

SARS-CoV-2 serology testing: Progress and challenges

AC Shi, P Ren - Journal of immunological methods, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused the most
devasting social and economic impact of this century. The current pandemic will end only …

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

JJ Guthmiller, O Stovicek, J Wang, S Changrob, L Li… - MBio, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a
global pandemic. The antigen specificity of the antibody response mounted against this …

[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics

ML Newby, CA Fogarty, JD Allen, J Butler… - Journal of Molecular …, 2023 - Elsevier
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …

Dynamics of SARS-CoV-2 spike proteins in cell entry: control elements in the amino-terminal domains

E Qing, T Kicmal, B Kumar, GM Hawkins, E Timm… - MBio, 2021 - Am Soc Microbiol
Selective pressures drive adaptive changes in the coronavirus spike proteins directing virus-
cell entry. These changes are concentrated in the amino-terminal domains (NTDs) and the …

Convalescent-phase sera and vaccine-elicited antibodies largely maintain neutralizing titer against global SARS-CoV-2 variant spikes

T Tada, BM Dcosta, MI Samanovic, RS Herati… - MBio, 2021 - Am Soc Microbiol
The increasing prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants with spike protein mutations raises concerns that antibodies elicited by natural …

Sertraline is an effective SARS-CoV-2 entry inhibitor targeting the spike protein

Y Chen, Y Wu, S Chen, Q Zhan, D Wu, C Yang… - Journal of …, 2022 - Am Soc Microbiol
The global spread of the novel coronavirus severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the continuously emerging new variants underscore an urgent need for …

[HTML][HTML] Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants' interaction with ACE2 to understand the binding affinity and stability

J Verma, N Subbarao - Virology, 2021 - Elsevier
The fall of 2020 brought several new variants of SARS-CoV-2 circulating across the globe,
and the steadily increasing COVID-19 cases are responsible for the emergence of these …

D614G substitution of SARS-CoV-2 spike protein increases syncytium formation and virus titer via enhanced furin-mediated spike cleavage

YW Cheng, TL Chao, CL Li, SH Wang, HC Kao… - MBio, 2021 - Am Soc Microbiol
Since the D614G substitution in the spike (S) protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion …

[HTML][HTML] SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes

SC Wall, N Suryadevara, C Kim, AR Shiakolas… - Cell Reports …, 2023 - cell.com
From the beginning of the COVID-19 pandemic, children have exhibited different
susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …