Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments

F Zobdeh, A Ben Kraiem, MM Attwood… - British journal of …, 2021 - Wiley Online Library
Migraine is the sixth most prevalent disease globally, a major cause of disability, and it
imposes an enormous personal and socio‐economic burden. Migraine treatment is often …

Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta‐analysis

MN Nurathirah, MB Yazid, MN Norhayati… - Academic …, 2022 - Wiley Online Library
Objectives This review was designated to evaluate the efficacy of parenteral ketorolac in
treating acute migraine headache. Methods We searched databases Cochrane Central …

Drug-related side effects and adverse reactions in the treatment of migraine: a bibliometric and visual analysis

S Wei, H Lv, D Yang, L Zhang, X Li, Y Ning… - Frontiers in …, 2024 - frontiersin.org
Background Migraine imposes a substantial global burden, impacting patients and society.
Pharmacotherapy, as a primary treatment, entails specific adverse reactions. Emphasizing …

Randomized trial comparing low-vs high-dose IV dexamethasone for patients with moderate to severe migraine

BW Friedman, C Solorzano, BD Kessler, K Martorello… - Neurology, 2023 - AAN Enterprises
Background and Objectives Dexamethasone decreases the frequency of migraine
recurrence after emergency department (ED) discharge. However, the optimal dose of …

Second‐line interventions for migraine in the emergency department: A narrative review

F Kazi, M Manyapu, M Fakherddine… - … : The Journal of …, 2021 - Wiley Online Library
Objective Millions of patients present to US emergency departments (ED) annually for the
treatment of migraine. First‐line treatments, including metoclopramide, prochlorperazine …

[HTML][HTML] Efficacy of sumatriptan/placebo versus sumatriptan/propofol combination in acute migraine; a randomized clinical trial

RF Rad, AZ Sadrabad, M Jafari… - Archives of academic …, 2022 - ncbi.nlm.nih.gov
Methods: This triple-blind clinical trial involved patients who referred to two emergency
departments with acute migraine headaches. Patients were randomly assigned to control …

The effectiveness of parenteral agents for pain reduction in patients with migraine presenting to emergency settings: A systematic review and network analysis

SW Kirkland, L Visser, J Meyer… - … : The Journal of …, 2024 - Wiley Online Library
Objectives To assess the comparative effectiveness and safety of parenteral agents for pain
reduction in patients with acute migraine. Background Parenteral agents have been shown …

The effectiveness of parenteral agents to mitigate relapses after severe acute migraine headache presentations: A systematic review and network analysis

S Kirkland, J Meyer, L Visser… - … : The Journal of …, 2024 - Wiley Online Library
Objectives To compare the effectiveness of parenteral agents to reduce relapse in patients
with acute migraine and identify factors that predict relapse. Background Following …

The influence of metoclopramide on trigeminovascular nociception: Possible anti-migraine mechanism of action

A Dolgorukova, AV Osipchuk, AA Murzina, AY Sokolov - Neuroscience, 2020 - Elsevier
Metoclopramide is widely used as an abortive migraine therapy due to the advantage of
having not only antiemetic, but also analgesic properties. Despite the proven clinical efficacy …

Optimization of electrochemiluminescence experimental conditions for metoclopramide determination based on response surface methodology

F Yang, W Zhang, B Liu, Y Ji, Y Zhao, K Zhou - International Journal of …, 2020 - Elsevier
Based on the strongenhancement effect of metoclopramide on the
electrochemiluminescencesignal of Ru (bpy) 3 2+ on the platinum electrode, a novelmethod …