Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Cyclodextrins are useful functional excipients that have enjoyed widespread attention and
use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these …

Cyclodextrins have gained currency as useful solubilizing excipients with an ever increasing
list of beneficial properties and functionalities. Although their use in liquid dosage forms …

In this study, we select naproxen (NAP) as a reference drug and electrospun poly (ɛ-
caprolactone)(PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was …

Cyclodextrins (CDs) are oligosaccharides that self-assemble in aqueous solutions to form
transient clusters, nanoparticles and small microparticles. The critical aggregation …

Covalent organic frameworks (COF) are complex functional systems constructed with atomic
precision by linking well‐defined building blocks through robust covalent bonds. β …

Early formulations are prepared mostly for drug compounds at both discovery and preclinical
stages and are used to animals via various routes such as oral and intravenous dosing …

Mixed surfactants may improve the performance of surfactant-enhanced solubilization of
drugs and thus can serve as the tool for increased bioavalaibility, controlled drug release …

In recent years, with the widespread application of high-throughput screening technologies
in drug discovery, an increasing number of new chemical entities with extremely poor …

Recycling high speed counter-current chromatography (HSCCC) was successfully applied
to resolution of (R, S)-naproxen (NAP) using hydroxypropyl-β-cyclodextrin (HP-β-CD) as …