Several naturally occurring purine and pyrimidine nucleosides contain an amide linkage as
part of the heterocyclic aglycone. Enolization of the amide and conversion to leaving groups …

The discovery in 1959 of stable nitroxide‐based free radicals such as the prototypical 2, 2, 6,
6‐tetramethylpiperidine‐1‐oxyl (TEMPO) led to their use as electron spin resonance (ESR) …

Pyrimidine and purine nucleosides have a remarkable and comprehensive impact on
medicinal chemistry and pharmaceutical industries. They become key parts of the growing …

The first direct arylation via C− OH bond activation of tautomerizable heterocycles has been
achieved using phosphonium salts, on the basis of a combination of the phosphonium …

Reactions of Ot-butyldimethylsilyl-protected thymidine, 2′-deoxyuridine, and 3′-
azidothymidine (AZT) with (benzotriazol-1-yloxy) tris (dimethylamino) phosphonium …

A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and
pyrimidinones is described. Exposure of the heterocycle to 1 H-benzotriazol-1-yloxy-tris …

In 1884, Emil Fischer 1, 2 had recognised the fused heterocyclic system, imidazo [4, 5-d]
pyrimidine as a purine. In 1889, he had accomplished the first synthesis of purine. 3 In his …

Since the original report in 2004, phosphonium coupling has emerged as a new, mild,
efficient, chemoselective and versatile methodology for the direct C–C, C–N, C–O, and C–S …

CN coupling reactions were found to be attractive among researchers owing to the
importance of CN bond formation in heterocyclic synthesis. Hence CN bond formation via …

Cladribine, 2-chloro-2′-deoxyadenosine, is a highly efficacious, clinically used nucleoside
for the treatment of hairy cell leukemia. It is also being evaluated against other lymphoid …