Oncogenic roles of the PI3K/AKT/mTOR axis
M Aoki, T Fujishita - Viruses, genes, and cancer, 2017 - Springer
Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …
has been considered a promising therapeutic target. Many of the positive regulators of the …
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
N Hinz, M Jücker - Cell Communication and Signaling, 2019 - Springer
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
A Carnero, C Blanco-Aparicio, O Renner… - Current cancer drug …, 2008 - ingentaconnect.com
PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
PIK3CA mutation associates with improved outcome in breast cancer
Purpose: In breast cancer, somatic mutations in the PIK3CA gene are common. The
prognostic implication of these activating mutations remains uncertain as moderately sized …
prognostic implication of these activating mutations remains uncertain as moderately sized …
PTEN, more than the AKT pathway
C Blanco-Aparicio, O Renner, JFM Leal… - …, 2007 - academic.oup.com
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-
kinase (PI3K)/AKT constitute an important pathway regulating the signaling of multiple …
kinase (PI3K)/AKT constitute an important pathway regulating the signaling of multiple …
Estradiol-regulated microRNAs control estradiol response in breast cancer cells
P Bhat-Nakshatri, G Wang, NR Collins… - Nucleic acids …, 2009 - academic.oup.com
Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a
ligand for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). E2-inducible …
ligand for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). E2-inducible …
The PKB/AKT pathway in cancer
A Carnero - Current pharmaceutical design, 2010 - ingentaconnect.com
PKB/AKT constitutes an important pathway that regulates the signaling of multiple essential
biological processes. PTEN is a dual protein/lipid phosphatase whose main substrate is …
biological processes. PTEN is a dual protein/lipid phosphatase whose main substrate is …
[HTML][HTML] Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research
Y Liu, T Yin, Y Feng, MM Cona, G Huang… - … imaging in medicine …, 2015 - ncbi.nlm.nih.gov
Compared with transplanted tumor models or genetically engineered cancer models,
chemically induced primary malignancies in experimental animals can mimic the clinical …
chemically induced primary malignancies in experimental animals can mimic the clinical …
G protein-coupled receptor kinase 2 (GRK2) promotes breast tumorigenesis through a HDAC6-Pin1 axis
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related
cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase …
cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase …
[HTML][HTML] Mouse models of estrogen receptor-positive breast cancer
Breast cancer is the most frequent malignancy and second leading cause of cancer-related
deaths among women. Despite advances in genetic and biochemical analyses, the …
deaths among women. Despite advances in genetic and biochemical analyses, the …