Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of
metabolism, stress resistance and longevity. Apart from its role as an important redox carrier …

The p53 protein is modified by as many as 50 individual posttranslational modifications.
Many of these occur in response to genotoxic or nongenotoxic stresses and show …

There are seven SIRT isoforms in mammals, with diverse biological functions including gene
regulation, metabolism, and apoptosis. Among them, SIRT3 is the only sirtuin whose …

The p53 tumor suppressor exerts anti-proliferative effects, including growth arrest, apoptosis
and cell senescence, in response to various types of stress. Tight regulation of p53 …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

The epithelial-to-mesenchymal transition (EMT) is a crucial program for the invasion and
metastasis of epithelial tumors that involves loss of cell–cell adhesion and increased cell …