Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …

Aldosterone is a mineralocorticoid hormone that controls body fluid and electrolyte balance.
Excess aldosterone is associated with cardiovascular and metabolic diseases. Inflammation …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Hypertension is a complex condition and is the most common cardiovascular risk factor,
contributing to widespread morbidity and mortality. Approximately 90% of hypertension …

Based on global estimates, almost 10% of adults have diabetes, of whom 40% are estimated
to also have chronic kidney disease (CKD). Almost 2 decades ago, treatments targeting the …

Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

Hypertension and atrial fibrillation (AF) are 2 important public health priorities. Their
prevalence is increasing worldwide, and the 2 conditions often coexist in the same patient …

Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …