Xenotransplantation: a new era
AN Carrier, A Verma, M Mohiuddin, M Pascual… - Frontiers in …, 2022 - frontiersin.org
Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …
supply of human donor organs. In the United States, there are currently over 100,000 …
Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive
surgery that has revolutionized the treatment of patients with devastating injuries, including …
surgery that has revolutionized the treatment of patients with devastating injuries, including …
C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection
due to the presence of donor-specific antibodies and immunologic memory. Here we show …
due to the presence of donor-specific antibodies and immunologic memory. Here we show …
Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
S Bos, L Milross, AJ Filby, R Vos… - European Respiratory …, 2022 - Eur Respiratory Soc
Lung transplantation is the optimal treatment for selected patients with end-stage chronic
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …
Investigational drugs for the treatment of kidney transplant rejection
LK van Vugt, MR Schagen, A de Weerd… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Kidney transplant rejection remains an important clinical problem despite the
development of effective immunosuppressive therapy. Two major types of rejection are …
development of effective immunosuppressive therapy. Two major types of rejection are …
Allogeneic lymphocytes immunotherapy in female infertility: lessons learned and the road ahead
The endometrium is an essential tissue in the normal immunologic dialogue between the
mother and the conceptus, which is necessary for the proper establishment and …
mother and the conceptus, which is necessary for the proper establishment and …
Analysis of T and B Cell Epitopes to Predict the Risk of de novo Donor-Specific Antibody (DSA) Production After Kidney Transplantation: A Two-Center Retrospective …
S Sakamoto, K Iwasaki, T Tomosugi… - Frontiers in …, 2020 - frontiersin.org
Risk prediction of de novo donor specific antibody (DSA) would be very important for long
term graft outcome after organ transplantation. The purpose of this study was to elucidate the …
term graft outcome after organ transplantation. The purpose of this study was to elucidate the …
B cell immunity in lung transplant rejection-effector mechanisms and therapeutic implications
B Ohm, W Jungraithmayr - Frontiers in Immunology, 2022 - frontiersin.org
Allograft rejection remains the major hurdle in lung transplantation despite modern
immunosuppressive treatment. As part of the alloreactive process, B cells are increasingly …
immunosuppressive treatment. As part of the alloreactive process, B cells are increasingly …
Managing allorejection in off-the-shelf CAR-engineered cell therapies
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has revolutionized the
treatment of various diseases, including cancers and autoimmune disorders. However, all …
treatment of various diseases, including cancers and autoimmune disorders. However, all …
Engineering immune-evasive allogeneic cellular immunotherapies
Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to
their potential cost-effectiveness, scalability and on-demand availability. However, immune …
their potential cost-effectiveness, scalability and on-demand availability. However, immune …