H3–H4 histone chaperone pathways
Nucleosomes compact and organize genetic material on a structural level. However, they
also alter local chromatin accessibility through changes in their position, through the …
also alter local chromatin accessibility through changes in their position, through the …
The histone chaperoning pathway: from ribosome to nucleosome
AJ Pardal, F Fernandes-Duarte… - Essays in …, 2019 - portlandpress.com
Nucleosomes represent the fundamental repeating unit of eukaryotic DNA, and comprise
eight core histones around which DNA is wrapped in nearly two superhelical turns. Histones …
eight core histones around which DNA is wrapped in nearly two superhelical turns. Histones …
[HTML][HTML] DAXX adds a de novo H3. 3K9me3 deposition pathway to the histone chaperone network
A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …
until DNA deposition. They cooperate through the formation of histone co-chaperone …
[HTML][HTML] DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network
From biosynthesis to assembly into nucleosomes, histones are handed through a cascade
of histone chaperones, which shield histones from non-specific interactions. Whether …
of histone chaperones, which shield histones from non-specific interactions. Whether …
NASP maintains histone H3–H4 homeostasis through two distinct H3 binding modes
Histone chaperones regulate all aspects of histone metabolism. NASP is a major histone
chaperone for H3–H4 dimers critical for preventing histone degradation. Here, we identify …
chaperone for H3–H4 dimers critical for preventing histone degradation. Here, we identify …
Chromatin replication and histone dynamics
Inheritance of the DNA sequence and its proper organization into chromatin is fundamental
for genome stability and function. Therefore, how specific chromatin structures are restored …
for genome stability and function. Therefore, how specific chromatin structures are restored …
A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
Core histones package chromosomal DNA and regulate genomic transactions, with their
nuclear import and deposition involving importin-β proteins and a dedicated repertoire of …
nuclear import and deposition involving importin-β proteins and a dedicated repertoire of …
Evidence for the nuclear import of histones H3. 1 and H4 as monomers
MJ Apta‐Smith, JR Hernandez‐Fernaud… - The EMBO …, 2018 - embopress.org
Newly synthesised histones are thought to dimerise in the cytosol and undergo nuclear
import in complex with histone chaperones. Here, we provide evidence that human H3. 1 …
import in complex with histone chaperones. Here, we provide evidence that human H3. 1 …
[HTML][HTML] Interactions with histone H3 & tools to study them
WA Scott, EI Campos - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Histones are an integral part of chromatin and thereby influence its structure, dynamics, and
functions. The effects of histone variants, posttranslational modifications, and binding …
functions. The effects of histone variants, posttranslational modifications, and binding …
[HTML][HTML] Monobodies as tool biologics for accelerating target validation and druggable site discovery
Despite increased investment and technological advancement, new drug approvals have
not proportionally increased. Low drug approval rates, particularly for new targets, are linked …
not proportionally increased. Low drug approval rates, particularly for new targets, are linked …