The systemic spread of malignancies and the risk of cancer-associated thrombosis are
major clinical challenges in cancer therapy worldwide. As an important post-translational …

Neutrophils are innate immune cells that have a vital role in host defense systems.
Neutrophil extracellular traps (NETs) are one of neutrophils' defense mechanisms against …

Multiple myeloma is a plasma cell malignancy, which grows in the bone marrow (BM). The
major population of cells in the BM is represented by neutrophils and they can form …

Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD)
activity have been observed in several neurodegenerative diseases. PC is a …

Abstract Peptidyl arginine deiminase 4 (PAD4) is an important biocatalytic enzymes involved
in the conversion of protein arginine to citrulline, its dysregulation has a great impact on …

Peptidyl arginine deiminase (PAD) which mediates citrullination catalyzes the conversion of
arginine residues of protein peptide chains to citrulline residues. Citrullination can be …

Neutrophil extracellular traps (NETs) significantly contribute to various pathophysiological
conditions, including cardiovascular diseases. NET formation in the vasculature exhibits …

Citrullination is a post-translation modification of proteins, where the proteinaceous arginine
residues are converted to non-coded citrulline residues. The immune tolerance to such …

Background Nasopharyngeal carcinoma (NPC) has high incidence in Southern China and
is derived from the mucosal epithelium of the nasopharynx. Accumulating evidence has …

Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information
with the potential to modulate offspring phenotypes. Recent studies show that the small RNA …