Sensorineural hearing impairment is the most common form of hearing loss, and
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …

During the development of the central nervous system the reciprocal communication
between neurons and oligodendrocytes is essential for the generation of myelin, a …

Loss-of-function mutations in human SCN1A gene encoding Nav1. 1 are associated with a
severe epileptic disorder known as severe myoclonic epilepsy in infancy. Here, we …

The axon initial segment (AIS), located within the first 30 μm of the axon, has two essential
roles in generating action potentials and maintaining axonal identity. AIS assembly depends …

Voltage-gated Na+ (Nav) channels are highly concentrated at nodes of Ranvier in
myelinated axons and facilitate rapid action potential conduction. Autoantibodies to …

Voltage-gated sodium channels are concentrated in myelinated nerves at the nodes of
Ranvier flanked by paranodal axoglial junctions. Establishment of these essential nodal and …

Ion channel function is fundamental to the existence of life. In metazoans, the coordinate
activities of voltage-gated Na+ channels underlie cellular excitability and control neuronal …

Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory
conduction. In peripheral nerves, clustering of these channels along the axolemma is …

The fundamental roles of Schwann cells during peripheral nerve formation and regeneration
have been recognized for more than 100 years, but the cellular and molecular mechanisms …

Many factors contribute to nervous system dysfunction and failure to regenerate after injury
or disease. Here, we describe a previously unrecognized mechanism for nervous system …