Advances in genetics of migraine
HG Sutherland, CL Albury, LR Griffiths - The journal of headache and pain, 2019 - Springer
Background Migraine is a complex neurovascular disorder with a strong genetic component.
There are rare monogenic forms of migraine, as well as more common polygenic forms; …
There are rare monogenic forms of migraine, as well as more common polygenic forms; …
Motile cilia genetics and cell biology: big results from little mice
L Lee, LE Ostrowski - Cellular and Molecular Life Sciences, 2021 - Springer
Our understanding of motile cilia and their role in disease has increased tremendously over
the last two decades, with critical information and insight coming from the analysis of mouse …
the last two decades, with critical information and insight coming from the analysis of mouse …
PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle
Background: Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …
[HTML][HTML] PRDM16 maintains homeostasis of the intestinal epithelium by controlling region-specific metabolism
Metabolic pathways dynamically regulate tissue development and maintenance. However,
the mechanisms that govern the metabolic adaptation of stem or progenitor cells to their …
the mechanisms that govern the metabolic adaptation of stem or progenitor cells to their …
Oxidative stress regulates progenitor behavior and cortical neurogenesis
Orderly division of radial glial progenitors (RGPs) in the developing mammalian cerebral
cortex generates deep and superficial layer neurons progressively. However, the …
cortex generates deep and superficial layer neurons progressively. However, the …
The epigenetic state of PRDM16-regulated enhancers in radial glia controls cortical neuron position
The epigenetic landscape is dynamically remodeled during neurogenesis. However, it is not
understood how chromatin modifications in neural stem cells instruct the formation of …
understood how chromatin modifications in neural stem cells instruct the formation of …
PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function
H He, SM Bell, AK Davis, S Zhao, A Sridharan… - Nature …, 2024 - nature.com
While the critical role of NKX2-1 and its transcriptional targets in lung morphogenesis and
pulmonary epithelial cell differentiation is increasingly known, mechanisms by which …
pulmonary epithelial cell differentiation is increasingly known, mechanisms by which …
A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exercise
Exercise has been recognized as a beneficial factor for cognitive health, particularly in
relation to the hippocampus, a vital brain region responsible for learning and memory …
relation to the hippocampus, a vital brain region responsible for learning and memory …
PRDM12 in health and diseases
PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1)
homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc …
homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc …
Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice
Background Use of cannabidiol (CBD), the primary non-psychoactive compound found in
cannabis, has recently risen dramatically, while relatively little is known about the underlying …
cannabis, has recently risen dramatically, while relatively little is known about the underlying …