Interaction between the nervous and skeletal systems
The skeleton is one of the largest organ systems in the body and is richly innervated by the
network of nerves. Peripheral nerves in the skeleton include sensory and sympathetic …
network of nerves. Peripheral nerves in the skeleton include sensory and sympathetic …
[HTML][HTML] Hemodynamic stress shapes subchondral bone in osteoarthritis: an emerging hypothesis
Osteoarthritis (OA) is no longer regarded as a simple wear-and-tear problem of articular
cartilage. Instead, OA is a whole joint disorder involving both cartilaginous and non …
cartilage. Instead, OA is a whole joint disorder involving both cartilaginous and non …
Monitoring acetylcholinesterase level changes under oxidative stress through ESIPT-ICT-based near-infrared fluorescent probe
X Wei, T Zhu, Y Ma, J Sun, G Zheng, T Ma… - Sensors and Actuators B …, 2023 - Elsevier
Oxidative stress plays an important role in pathology, and contributes to a variety of
diseases, including inflammation, neurodegenerative diseases, and cancer. Research …
diseases, including inflammation, neurodegenerative diseases, and cancer. Research …
The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway
Acetylcholinesterase (AChE) is a highly conserved enzyme responsible for the regulation of
acetylcholine signaling within the brain and periphery. AChE has also been shown to …
acetylcholine signaling within the brain and periphery. AChE has also been shown to …
Validation of acetylcholinesterase inhibition machine learning models for multiple species
PA Vignaux, TR Lane, F Urbina, J Gerlach… - Chemical research in …, 2023 - ACS Publications
Acetylcholinesterase (AChE) is an important enzyme and target for human therapeutics,
environmental safety, and global food supply. Inhibitors of this enzyme are also used for pest …
environmental safety, and global food supply. Inhibitors of this enzyme are also used for pest …
In vitro inhibition of acetylcholinesterase activity by yellow field pea (Pisum sativum) protein-derived peptides as revealed by kinetics and molecular docking
Compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly
used to inhibit the activity of acetylcholinesterase (AChE) in Alzheimer's disease (AD) …
used to inhibit the activity of acetylcholinesterase (AChE) in Alzheimer's disease (AD) …
Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis
Y Yoshikawa, T Izawa, Y Hamada, H Takenaga… - Scientific reports, 2021 - nature.com
Bone loss due to smoking represents a major risk factor for fractures and bone osteoporosis.
Signaling through the aryl hydrocarbon receptor (AhR) and its ligands contributes to both …
Signaling through the aryl hydrocarbon receptor (AhR) and its ligands contributes to both …
Roles of hybrid donepezil scaffolds as potent human acetylcholinesterase inhibitors using in silico interaction analysis, drug-likeness, and pharmacokinetics prediction
P Honorio, S Hannongbua, P Saparpakorn - Chemico-Biological …, 2022 - Elsevier
Acetylcholinesterase (AChE) is currently one of the potent targets for the treatment of
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …
Untargeted metabolomics reveal the protective effect of bone marrow mesenchymal stem cell transplantation against ovariectomy-induced osteoporosis in mice
W Wang, Y Wang, J Hu, H Duan, Z Wang… - Cell …, 2022 - journals.sagepub.com
Bone marrow mesenchymal stem cell transplantation (BMSCT) is a potential treatment for
osteoporosis, capable of contributing to bone tissue repair. BMSCT has demonstrated …
osteoporosis, capable of contributing to bone tissue repair. BMSCT has demonstrated …
In silico and in vitro methods in the characterization of beta-carotene as pharmaceutical material via acetylcholine esterase inhibitory actions
A Muthuraman, M Ramesh, F Mustaffa, A Nadeem… - Molecules, 2023 - mdpi.com
Molecular docking is widely used in the assessment of the therapeutic potential of
pharmaceutical agents. The binding properties of beta-carotene (BC) to acetylcholine …
pharmaceutical agents. The binding properties of beta-carotene (BC) to acetylcholine …