Methods: Studies were identified searching Medline, Embase, Web of Science, and the
Cochrane Library. Studies published until 4 th May 2021 were included. We only considered …

The microbiome plays an important role in maintaining human health. Despite multiple
factors being attributed to the shaping of the human microbiome, extrinsic factors such diet …

Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …

Western diet (WD) intake, aging, and inactivation of farnesoid X receptor (FXR) are risk
factors for metabolic and chronic inflammation-related health issues ranging from metabolic …

Background Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X
receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into …

The Western diet can negatively affect the gut microbiota and is associated with metabolic
disorders. Kombucha, a tea fermented by a symbiotic culture of bacteria and yeast (SCOBY) …

Aims: Trimethylamine-N-oxide (TMAO) is a metabolite generated from dietary choline,
betaine, and l-carnitine, after their oxidization in the liver. TMAO has been identified as a …

Background/Objectives Leptin is an adipokine secreted in proportion to adipocyte mass and
is therefore increased in obesity. Leptin signaling has been shown to directly promote …

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by
dietary, environmental, and genetic factors. While the incidence of IBD is increasing …

Delivery of effective anti-leukemic agents to the central nervous system (CNS) is considered
essential for cure of childhood acute lymphoblastic leukemia. Current CNS-directed therapy …