Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show …

In vivo protein-DNA interactions connect each transcription factor with its direct targets to
form a gene network scaffold. To map these protein-DNA interactions comprehensively …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Highlights•Identified as a master regulator of neuronal genes in embryogenesis, REST is a
common theme in neurodegeneration.•Whereas bioinformatics predicts∼ 2000 REST …

Brain‐derived neurotrophic factor (BDNF) has important functions in the development of the
nervous system and in brain plasticity‐related processes such as memory, learning, and …

Regulation of neuronal gene expression is critical to central nervous system development.
Here, we show that REST regulates the transitions from pluripotent to neural stem/progenitor …

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …

The transcription factor REST silences neuronal gene expression in non-neuronal cells. In
neurons, the protein is sequestered in the cytoplasm in part through binding to huntingtin …