The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …

Protein glycosylation is a posttranslational modification that affects more than half of all
known proteins. Glycans covalently bound to biomolecules modulate their functions by both …

It is well recognized that the majority of cancer related deaths is caused by metastatic
diseases. Therefore, there is an urgent need for the development of therapeutic intervention …

Alterations in glycosylation are common in cancer and are thought to contribute to disease.
Lung cancer and primary malignant brain cancer, most commonly glioblastoma, are …

Most of the metabolic needs of erythrocytes are covered by glycolysis, the oxidative pentose
phosphate pathway and the glutathione cycle. Hereditary enzyme deficiencies of all these …

Autocrine motility factor (AMF) stimulates cell motility in an autocrine manner and is related
to tumor malignancy. AMF is a multifunctional molecule, also known as phosphoglucose …

Cardiovascular disease (CVD), diabetes and cancer pose increasing global healthcare
burdens. New biomarkers could enable earlier diagnosis of these diseases, leading to more …

Autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) is a ubiquitous cytosolic
enzyme and is produced as a leaderless secretory protein, released from cells via a …

Phosphohexose isomerase (PHI) is a member of the ectoenzyme/exoenzyme family and
plays a key role in both glycolysis and gluconeogenesis pathways. Upon secretion PHI acts …

The hallmark of tumor metastasis is the dissemination of cells from the primary growth site
todistant organs. Autocrine motility factor (AMF), a tumor-associated CXXC cytokine, the …