Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma
M Rosellini, A Marchetti, V Mollica, A Rizzo… - Nature Reviews …, 2023 - nature.com
The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of
immunotherapy agents by regulatory agencies. However, objective and durable responses …
immunotherapy agents by regulatory agencies. However, objective and durable responses …
Base excision repair and its implications to cancer therapy
GJ Grundy, JL Parsons - Essays in biochemistry, 2020 - portlandpress.com
Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
PARPi treatment enhances radiotherapy-induced ferroptosis and antitumor immune responses via the cGAS signaling pathway in colorectal cancer
D Shen, J Luo, L Chen, W Ma, X Mao, Y Zhang… - Cancer Letters, 2022 - Elsevier
In cancer cells, poly (ADP-ribose) polymerase (PARP)-1 and PARP2 initiate and regulate
DNA repair pathways to protect against DNA damage and cell death caused by radiotherapy …
DNA repair pathways to protect against DNA damage and cell death caused by radiotherapy …
PARP inhibitor plus radiotherapy reshapes an inflamed tumor microenvironment that sensitizes small cell lung cancer to the anti-PD-1 immunotherapy
N Zhang, Y Gao, Z Huang, P Dai, Y Luo, Q Wu, X Jiang… - Cancer Letters, 2022 - Elsevier
Small cell lung cancer (SCLC) is a highly malignant tumor with extremely poor prognosis.
The treatment strategy is very limited, and patient outcomes remain dismal with the 5-year …
The treatment strategy is very limited, and patient outcomes remain dismal with the 5-year …
Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors
PA Laurent, D Morel, L Meziani, S Depil… - …, 2023 - Taylor & Francis
Chimeric antigen receptor (CAR)-T cells have demonstrated significant improvements in the
treatment of refractory B-cell malignancies that previously showed limited survival. In …
treatment of refractory B-cell malignancies that previously showed limited survival. In …
The synergistic effect of PARP inhibitors and immune checkpoint inhibitors
Z Wu, P Cui, H Tao, S Zhang, J Ma… - Clinical Medicine …, 2021 - journals.sagepub.com
Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated great promise for
treating cancers with homologous recombination (HR) defects, such as germline BRCA1/2 …
treating cancers with homologous recombination (HR) defects, such as germline BRCA1/2 …
Olaparib enhances radiation-induced systemic anti-tumor effects via activating STING-chemokine signaling in hepatocellular carcinoma
G Chen, D Zheng, Y Zhou, S Du, Z Zeng - Cancer Letters, 2024 - Elsevier
Although Poly (ADP-ribose) polymerase (PARP) inhibitors have been clinically approved for
cancers with BRCA mutations and are known to augment radiotherapy responses, their …
cancers with BRCA mutations and are known to augment radiotherapy responses, their …
Targeting neuropilin-1 interactions is a promising anti-tumor strategy
SD Liu, LP Zhong, J He, YX Zhao - Chinese Medical Journal, 2021 - mednexus.org
Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in
nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in …
nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in …
How to overcome tumor resistance to anti-PD-1/PD-L1 therapy by immunotherapy modifying the tumor microenvironment in MSS CRC
L Chen, X Jiang, Y Li, Q Zhang, Q Li, X Zhang… - Clinical …, 2022 - Elsevier
Immune checkpoint inhibitors (ICIs), including anti-programmed cell death-1/anti-
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …
Dying of stress: chemotherapy, radiotherapy, and small-molecule inhibitors in immunogenic cell death and immunogenic modulation
Innovative strategies to re-establish the immune-mediated destruction of malignant cells is
paramount to the success of anti-cancer therapy. Accumulating evidence suggests that …
paramount to the success of anti-cancer therapy. Accumulating evidence suggests that …