A decennary update on diverse heterocycles and their intermediates as privileged scaffolds for cathepsin B inhibition
The identification of x-ray crystal structure of cathepsin B (CTSB) in the early 90's enabled
researchers to embark on a journey to understand and demystify its multiple catalytic …
researchers to embark on a journey to understand and demystify its multiple catalytic …
Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies
Enzymes are the biological macromolecules that have emerged as an important drug target
as their upregulation/imbalance leads to various pathological conditions, such as …
as their upregulation/imbalance leads to various pathological conditions, such as …
Synthesis and biological evaluation of substituted aurone derivatives as potential tyrosinase inhibitors: in vitro, kinetic, QSAR, docking and drug-likeness studies
NA Alshaye, EU Mughal, EB Elkaeed… - Journal of …, 2023 - Taylor & Francis
Tyrosinase enzyme plays an essential role in melanin biosynthesis and enzymatic browning
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
1, 2, 3-triazole clubbed and dichloro substituted novel aurones as potential anticancer agents targeting digestive enzymes: Design, synthesis, DFT, ADME and …
In the present investigation, we engineered some 1, 2, 3-triazole clubbed and dichloro
substituted novel aurones as potential anticancer agents well capable of targeting digestive …
substituted novel aurones as potential anticancer agents well capable of targeting digestive …
[HTML][HTML] Ultrasound assisted a one pot multicomponent and greener synthesis of 1, 2, 3-triazole incorporated aurone hybrids: Cathepsin B inhibition, anti-cancer …
Cathepsin B represents a group of lysosomal-encapsulated cellular cysteine proteases,
whose upregulation is the critical risk factor for cancer progression and in the regulation of …
whose upregulation is the critical risk factor for cancer progression and in the regulation of …
[HTML][HTML] Novel 1, 2, 3-triazole-aurone hybrids as cathepsin B inhibitors: One-pot synthesis, anti-proliferative, and drug modeling studies
In the present study, we have designed a series of novel 1, 2, 3-triazole-aurone hybrids,
which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ …
which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ …
Design, synthesis, biological evaluation, and molecular docking studies of some novel N,N‐dimethylaminopropoxy‐substituted aurones
In continuation of our ongoing research on the discovery of novel and potentially bioactive
aurones, we have designed and synthesized some novel N, N‐dimethylaminopropoxy …
aurones, we have designed and synthesized some novel N, N‐dimethylaminopropoxy …
Synthetic and Biological Studies of Some Pyrrolidine-Tethered Novel Aurones against Digestive Enzymes
Amylase, lipase, and trypsin are crucial digestive enzymes, whose activation or inhibition is
of potent therapeutic approach for treating various body disorders. In this work, we have …
of potent therapeutic approach for treating various body disorders. In this work, we have …
Cinnamaldehyde hydrazone derivatives as potential cathepsin B inhibitors: A parallel in-vitro investigation in liver and cerebrospinal fluid
C Vashisth, T Kaushik, N Vashisth, N Raghav - International Journal of …, 2024 - Elsevier
The emergence of cathepsins as a potential target for anticancer drugs has led to extensive
research in the development of their inhibitors. In the present study, we designed …
research in the development of their inhibitors. In the present study, we designed …
Design, synthesis, molecular docking and biological studies of some novel pyrrolidine-triazole-aurone hybrids against digestive enzymes
Here in this work we successfully designed and synthesized a library of some novel
pyrrolidine-triazole-aurone hybrids ie (Z)-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl) ethyl)-1 H …
pyrrolidine-triazole-aurone hybrids ie (Z)-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl) ethyl)-1 H …