The electron transport chain (ETC) couples electron transfer with proton pumping to
generate ATP and it also regulates particular innate and adaptive immune cell function …

Stroke is one of the leading causes of morbidity and mortality worldwide. A main cause of
brain damage by stroke is ischemia-reperfusion (IR) injury due to the increased production …

In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of
cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were …

Significance: Dimeric nicotinamide nucleotide transhydrogenase (NNT) is embedded in the
mitochondrial inner membrane and couples the conversion of NADP+/NADH into …

Isobavachalcone (IBC) is a natural small molecule with various biological activities;
however, its inhibitory effects on Cryptococcus neoformans remain unclear. In our study, IBC …

Hidden confounding biases hinder identifying causal protein biomarkers for Alzheimer's
disease in non-randomized studies. While Mendelian randomization (MR) can mitigate …

It is unclear whether mitochondrial dysfunction and redox stress contribute to impaired age-
related muscle regenerative capacity. Here we characterized a novel compound, BI4500 …

Although myeloid-derived suppressor cells (MDSCs) are critical for allograft survival, their
regulatory mechanism remains unclear. Herein, our results showed that metabolism sensor …

Aerobic organisms use molecular oxygen in several reactions, including those in which the
oxidation of substrate molecules is coupled to oxygen reduction to produce large amounts of …

Microglia, the resident macrophages of the brain, are derived from the yolk sac and colonize
the brain before the blood-brain barrier forms. Once established, they expand locally and …