Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Design principles for therapeutic angiogenic materials

PS Briquez, LE Clegg, MM Martino… - Nature Reviews …, 2016 - nature.com
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

LR Nih, S Gojgini, ST Carmichael, T Segura - Nature materials, 2018 - nature.com
Stroke is the primary cause of disability due to the brain's limited ability to regenerate
damaged tissue. After stroke, an increased inflammatory and immune response coupled …

Electropolymerization of dopamine for surface modification of complex-shaped cardiovascular stents

J Wang, B Li, Z Li, K Ren, L Jin, S Zhang, H Chang… - Biomaterials, 2014 - Elsevier
Inspired by the adhesion strategy of marine mussels, self-polymerization of dopamine under
alkaline condition has been proven to be a simple and effective method for surface …

Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake

SY Ko, WJ Lee, HA Kenny, LH Dang, LM Ellis… - Communications …, 2019 - nature.com
Cancer-derived small extracellular vesicles (sEVs) induce stromal cells to become
permissive for tumor growth. However, it is unclear whether this induction solely occurs …

Engineered culture models for studies of tumor-microenvironment interactions

DW Infanger, ME Lynch… - Annual review of …, 2013 - annualreviews.org
Heterogeneous microenvironmental conditions play critical roles in cancer pathogenesis
and therapy resistance and arise from changes in tissue dimensionality, cell-extracellular …

The use of covalently immobilized stem cell factor to selectively affect hematopoietic stem cell activity within a gelatin hydrogel

BP Mahadik, SP Haba, LJ Skertich, BAC Harley - Biomaterials, 2015 - Elsevier
Hematopoietic stem cells (HSCs) are a rare stem cell population found primarily in the bone
marrow and responsible for the production of the body's full complement of blood and …

Design of growth factor sequestering biomaterials

DG Belair, NN Le, WL Murphy - Chemical Communications, 2014 - pubs.rsc.org
Growth factors (GFs) are major regulatory proteins that can govern cell fate, migration, and
organization. Numerous aspects of the cell milieu can modulate cell responses to GFs, and …

The modulation of MSC integrin expression by RGD presentation

J Lam, T Segura - Biomaterials, 2013 - Elsevier
Biomaterials designed to mimic the intricate native extracellular matrix (ECM) can use a
variety of techniques to control the behavior of encapsulated cells. Common methods …

Receptor-ligand interactions: Advanced biomedical applications

I Guryanov, S Fiorucci, T Tennikova - Materials Science and Engineering …, 2016 - Elsevier
Receptor-ligand interactions (RLIs) are at the base of all biological events occurring in living
cells. The understanding of interactions between complementary macromolecules in …