Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis
The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …
Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology
Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …
[HTML][HTML] Mechanistic elucidation of Juglanthraquinone C targeting breast cancer: a network pharmacology-based investigation
H Qayoom, M Alkhanani, A Almilaibary… - Saudi Journal of …, 2023 - Elsevier
Breast cancer is the leading cause of death among women worldwide. Despite the recent
treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming …
treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming …
Molecular modeling and in vitro antiproliferative activity studies of some imidazole and isoxazole derivatives
MT Muhammed, ER Mustafa, S Akkoc - Journal of Molecular Structure, 2023 - Elsevier
Five compounds were synthesized and tested as in vitro against two different cancer cell
lines to find out their antiproliferative activities. The results showed that a compound …
lines to find out their antiproliferative activities. The results showed that a compound …
A network pharmacology-based investigation of brugine reveals its multi-target molecular mechanism against Breast Cancer
Breast cancer represents the leading cause of mortality among women worldwide. Since the
complexity of breast cancer as a disease resides in its heterogeneity as it consists of several …
complexity of breast cancer as a disease resides in its heterogeneity as it consists of several …
Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941
Although advances in diagnostics and therapeutics have prolonged the survival of triple-
negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of …
negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of …
Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral …
A significant portion of human cancers are caused by oncoviruses (12%–25%). Oncoviruses
employ various strategies to promote their replication and induce tumourigenesis in host …
employ various strategies to promote their replication and induce tumourigenesis in host …
[HTML][HTML] A comprehensive analysis of notch signaling genes in breast cancer: expression pattern and prognostic significance
The most recurrent type of cancer among women is breast cancer which is an intricate
disease with high intertumoral and intratumoral heterogeneity. Such variability is a key factor …
disease with high intertumoral and intratumoral heterogeneity. Such variability is a key factor …
Cell cycle dysregulation in breast cancer
Cancer, a condition characterized by abnormal cell growth, is closely linked to the cell cycle.
In reaction to mitogenic cues, all malignancies comprise an aberrant buildup of tumor …
In reaction to mitogenic cues, all malignancies comprise an aberrant buildup of tumor …
[HTML][HTML] Elucidation of interleukin-19 as a therapeutic target for breast cancer by computational analysis and experimental validation
Abstract Interleukin 19 (IL-19) is a cytokine produced by monocytes and belongs to the
family of IL-10. The IL-19 protein stimulates fibronectin (FN) expression and assembly …
family of IL-10. The IL-19 protein stimulates fibronectin (FN) expression and assembly …