The kidney filters vast quantities of Na at the glomerulus but excretes a very small fraction of
this Na in the final urine. Although almost every nephron segment participates in the …

Cholangiocytes are epithelial cells that line the intra-and extrahepatic ducts of the biliary
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …

All cells release nucleotides and are in one way or another involved in local autocrine and
paracrine regulation of organ function via stimulation of purinergic receptors. Significant …

In this study, we examined the Ca2+-permeable Piezo1 channel, a newly identified
mechanosensing ion channel, in human dental pulp-derived mesenchymal stem cells …

Mechanical forces associated with fluid flow and/or circumferential stretch are sensed by
renal epithelial cells and contribute to both adaptive or disease states. Non‐selective stretch …

Polycystins are a family of eight-transmembrane proteins united by sequence homology.
The name stems from the identification of mutations in genes encoding polycystin-1 and-2 in …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Visualization of signal transduction in live primary cilia constitutes a technical challenge
owing to the organelle's submicrometer dimensions and close proximity to the cell body …

Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, contain primary cilia, which
are mechano-and osmosensory organelles detecting changes in bile flow and osmolality …

Nucleotides are key subunits for nucleic acids and provide energy for intracellular
metabolism. They can also be released from cells to act physiologically as extracellular …