Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Acute kidney injury (AKI) is a common and serious problem affecting millions and causing
death and disability for many. In 2012, Kidney Disease: Improving Global Outcomes …

Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the
inner ear. Due to their popular application as a result of their potent antimicrobial activities …

Objective: To assess relative efficacy and toxicity of aminoglycosides given by single daily
dose compared with multiple daily doses. Design: Meta-analysis of 21 randomised trials …

Pulmonary exacerbations have very important consequences in cystic fibrosis (CF), both in
terms of current morbidity as well as implications for long term morbidity and mortality. Even …

Objective: To compare the efficacy, nephrotoxicity, and ototoxicity of once-daily
aminoglycoside dosing with those of standard aminoglycoside regimens in …

Introduction In the time of increasing resistance and paucity of new drug development there
is a growing need for strategies to enhance rational use of antibiotics in German and …

Las bronquiectasias son el resultado final de enfermedades diferentes que tienen puntos de
manejo comunes. Suelen cursar con infección e inflamación bronquiales crónicas que se …

Despite their toxicity, aminoglycosides continue to play a pivotal role in the management of
serious infections. Indeed, their toxicity has led to comparatively restrained usage, and as a …