Abstract Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during
type 2 immune responses, are critical for protective immunity against infections of …

Allergic inflammation is a type 2 immune disorder classically characterized by high levels of
immunoglobulin E (IgE) and the development of Th2 cells. Asthma is a pulmonary allergic …

CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …

The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a
decade ago, the NFAT family of transcription factors has grown to include five members. It …

CD4+ T cells, also known as T‐helper (Th) cells, play an important role in orchestrating
adaptive immune responses to various infectious agents. They are also involved in the …

The role of DNA methylation and of the maintenance DNA methyltransferase Dnmt1 in the
epigenetic regulation of developmental stage-and cell lineage-specific gene expression in …

T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive
immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLO …

After encountering antigen, helper T (TH) cells undergo differentiation to effector cells, which
can secrete high levels of interferon-γ, interleukin-4 (IL-4), IL-10 and other …

T follicular helper (TFH) cells select high-affinity, antibody-producing B cells for clonal
expansion in germinal centers (GCs), but the nature of their interaction is not well defined …