Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria
Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains
largely unknown how the capsules enhance bacterial virulence under in vivo infection …
largely unknown how the capsules enhance bacterial virulence under in vivo infection …
Biological puzzles solved by using Streptococcus pneumoniae: a historical review of the pneumococcal studies that have impacted medicine and shaped molecular …
NL Hiller, CJ Orihuela - Journal of Bacteriology, 2024 - Am Soc Microbiol
The major human pathogen Streptococcus pneumoniae has been the subject of intensive
clinical and basic scientific study for over 140 years. In multiple instances, these efforts have …
clinical and basic scientific study for over 140 years. In multiple instances, these efforts have …
PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites
Streptococcus pneumoniae (Spn) resides in the nasopharynx, where it can disseminate to
cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA) …
cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA) …
Detoxification of reactive oxygen species by the hyaluronic acid capsule of group A Streptococcus
S Wilde, A Dash, A Johnson, K Mackey… - Infection and …, 2023 - Am Soc Microbiol
The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly
crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of …
crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of …
Host immunity involvement in the outcome of phage therapy against hypervirulent Klebsiella pneumoniae infections
M Tang, Z Yao, Y Liu, Z Ma, D Zhao… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Highly encapsulated hypervirulent Klebsiella pneumoniae (hvKp) causes severe infections.
Bacteriophage therapy, an antibiotic alternative, effectively treats bacterial infections. Phage …
Bacteriophage therapy, an antibiotic alternative, effectively treats bacterial infections. Phage …
Capsule-deficient group A Streptococcus evades autophagy-mediated killing in macrophages
The hyaluronic acid capsule is crucial in protecting group A Streptococcus (GAS) against
phagocytic killing. However, there have been reported outbreaks caused by capsule …
phagocytic killing. However, there have been reported outbreaks caused by capsule …