Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Carbon monoxide (CO) is increasingly recognized as a cell-signalling molecule akin to nitric
oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of …

Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

Carbon monoxide (CO) is an endogenous small signalling molecule in the human body,
produced by the action of haem oxygenase on haem. Since it is very difficult to apply safely …

Carbon monoxide (CO) and hydrogen sulfide (H 2 S) used to be thought of simply as lethal
and (for H 2 S) smelly gaseous molecules; now they are known to have important signaling …

Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

Abstract Heme oxygenase-1 (HO-1) catalyzes heme degradation to generate biliverdin-IXα,
carbon monoxide (CO), and iron. The HO-1/CO system confers cytoprotection in animal …

The first descriptions of carbon monoxide (CO) and its toxic nature appeared in the literature
over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men …

Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …