DNA double strand breaks (DSB) are cytotoxic lesions that can lead to genome
rearrangements and genomic instability, which are hallmarks of cancer. The two main DSB …

Recombinases are responsible for homologous recombination and maintenance of genome
integrity. In Escherichia coli, the recombinase RecA forms a nucleoprotein filament with the …

Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR),
a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay …

Homologous recombination (HR) is a primary DNA double-strand breaks (DSBs) repair
mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; …

The vast majority of eukaryotes possess two DNA recombinases: Rad51, which is
ubiquitously expressed, and Dmc1, which is meiosis-specific. The evolutionary origins of this …

Ensuring balanced distribution of chromosomes in gametes, meiotic recombination is
essential for fertility in most sexually reproducing organisms. The repair of the programmed …

Both high-fidelity and mismatch-tolerant recombination, catalyzed by RAD51 and DMC1
recombinases, respectively, are indispensable for genomic integrity. Here, we use cryo-EM …

Homologous recombination during meiosis is crucial for the DNA double-strand breaks
(DSBs) repair that promotes the balanced segregation of homologous chromosomes and …

The demand for direct observation of biomolecular interactions provides new insights into
the molecular mechanisms underlying many biological processes. Single-molecule imaging …

Crossover recombination is critical for meiotic chromosome segregation, but how
mammalian crossing over is accomplished is poorly understood. Here, we illuminate how …