Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …

Exosomes are extracellular vesicles that influence cellular behavior and enhance cancer
aggressiveness by carrying bioactive molecules. The mechanisms that regulate exosome …

The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13
amplicon, one of the most frequently amplified chromosomal regions in human cancer, but …

Oral cancer represents a common entity comprising a third of all head and neck malignant
tumors. The options for curative treatment of oral cavity cancer have not changed …

Branched actin assembly is critical for a variety of cellular processes that underlie cell
motility and invasion, including cellular protrusion formation and membrane trafficking …

Laryngeal carcinoma is the second common malignancy of the upper aerodigestive tract
after lung cancer; in most cases is a squamous cell carcinoma, whose risk factors include …

Background: Head and neck squamous cell carcinoma (HNSCC) is associated with poor
survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied …

Head and neck tumors belong among the six leading causes of cancer death worldwide.
The predominant type of head and neck tumors consists of squamous cell carcinomas …

Abstract DOG1 (discovered on GIST 1), known also as TMEM16A and ANO1, has emerged
in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was …