Tuberculosis (TB) is an infectious disease that poses a serious threat to human health.
Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key …

Pyrazinamide (PZA) is an essential first-line tuberculosis drug for its unique mechanism of
action active against multidrug-resistant-TB (MDR-TB). Thus, the aim of updated meta …

Our objective was to evaluate the performance of whole-genome sequencing (WGS) from
early positive liquid cultures for predicting Mycobacterium tuberculosis complex (MTBC) …

Background Leveraging well-established DNA-level drug resistance mechanisms, whole-
genome sequencing (WGS) has emerged as a valuable methodology for predicting drug …

This study aims to conduct a comprehensive molecular dynamics strategy to evaluate
whether mutations found in pyrazinamide monoresistant (PZAMR) strains of Mycobacterium …

Tuberculosis (TB) is still one of the leading causes of worldwide death, especially following
the emergence of strains resistant to isoniazid (INH) and rifampicin (RIF). This study aimed …

Objectives It is established that resistance to rifampicin (RIF) in 90% of RIF-resistant
Mycobacterium tuberculosis isolates is attributable to point mutations in the rpoB gene …

Introduction. Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem
globally, including in Indonesia. Whole-genome sequencing (WGS) analysis has rarely …

Objective To evaluate the performance of whole-genome sequencing (WGS) for predicting
Mycobacterium tuberculosis (MTB) drug resistance. Methods 276 rifampin-resistance …

Introduction Infectious diseases still cause a significant burden of morbidity and mortality
among children in low-and middle-income countries (LMICs). There are ample opportunities …