Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a
contractile phenotype that maintains the normal vessel structure and function under …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Atherosclerosis, a chronic cardiovascular disease caused by plaque development in
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …

Glucocorticoids are steroid hormones with key roles in the regulation of many physiological
systems including energy homeostasis and immunity. However, chronic glucocorticoid …

Vascular remodeling is a common pathological hallmark of many cardiovascular diseases.
Vascular smooth muscle cells (VSMCs) are the predominant cell type lining the tunica media …

Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels
the development of advanced technologies for CVD diagnosis and treatment. Biomarker …

Vascular smooth muscle cells (VSMCs) can transdifferentiate into macrophage-like cells in
the context of sustained inflammatory injury, which drives vascular hyperplasia and …

Background Macrophage-like transformation of vascular smooth muscle cells (VSMCs) is a
risk factor of atherosclerosis (AS) progression. Transcription factor homeobox A1 (HOXA1) …