The current state of eukaryotic DNA base damage and repair
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
SUMO-SIM interactions: From structure to biological functions
J Lascorz, J Codina-Fabra, D Reverter… - Seminars in Cell & …, 2022 - Elsevier
Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …
numerous cellular processes. This modification involves the covalent and reversible …
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
SUMO-mediated regulation of DNA damage repair and responses
P Sarangi, X Zhao - Trends in biochemical sciences, 2015 - cell.com
Sumoylation has important roles during DNA damage repair and responses. Recent broad-
scope and substrate-based studies have shed light on the regulation and significance of …
scope and substrate-based studies have shed light on the regulation and significance of …
Recent advances in the structural mechanisms of DNA glycosylases
SC Brooks, S Adhikary, EH Rubinson… - Biochimica et Biophysica …, 2013 - Elsevier
DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …
Base excision repair, a pathway regulated by posttranslational modifications
RJ Carter, JL Parsons - Molecular and cellular biology, 2016 - Taylor & Francis
Base excision repair (BER) is an essential DNA repair pathway involved in the maintenance
of genome stability and thus in the prevention of human diseases, such as premature aging …
of genome stability and thus in the prevention of human diseases, such as premature aging …
DNA damage–inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger
JR Danielsen, LK Povlsen, BH Villumsen… - Journal of Cell …, 2012 - rupress.org
Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid (DNA) double-
strand breaks (DSBs) by the RNF8/RNF168/HERC2 ubiquitin ligases facilitates restoration …
strand breaks (DSBs) by the RNF8/RNF168/HERC2 ubiquitin ligases facilitates restoration …
SUMO‐regulated transcription: challenging the dogma
P Chymkowitch, A Nguéa P, JM Enserink - Bioessays, 2015 - Wiley Online Library
The small ubiquitin‐like modifier SUMO regulates many aspects of cellular physiology to
maintain cell homeostasis, both under normal conditions and during cell stress …
maintain cell homeostasis, both under normal conditions and during cell stress …
SUMO, a small, but powerful, regulator of double-strand break repair
AJ Garvin, JR Morris - … of the Royal Society B: Biological …, 2017 - royalsocietypublishing.org
The response to a DNA double-stranded break in mammalian cells is a process of sensing
and signalling the lesion. It results in halting the cell cycle and local transcription and in the …
and signalling the lesion. It results in halting the cell cycle and local transcription and in the …
[HTML][HTML] The ubiquitin-and SUMO-dependent signaling response to DNA double-strand breaks
S Bekker-Jensen, N Mailand - FEBS letters, 2011 - Elsevier
DNA double-strand breaks (DSBs) represent the most destructive type of chromosomal
lesion and trigger rapid chromatin restructuring accompanied by accumulation of proteins in …
lesion and trigger rapid chromatin restructuring accompanied by accumulation of proteins in …