The concept of three-dimensional (3D) cell culture has been proposed to maintain cellular
morphology and function as in vivo. Among different approaches for 3D cell culture …

Cell adhesion molecules (CAMs) play a significant role in the metastatic potential of
colorectal cancer and thus mediate the prognosis of this common malignancy. The …

Background: The tumor three-dimensional (3D) spheroid model in vitro is effective on
detecting malignant cells and tumorigenesis, and assessing drug resistance. Compared with …

by Lisa A. Gurski, BS; Nicholas J. Petrelli, MD; Xinqiao Jia, PhD; and Mary C. Farach-
Carson, PhD vivo, both the ECM and the mechanical properties of the 3D environment affect …

Tumor dormancy is a poorly understood stage in cancer progression characterized by
mitotic cycle arrest in G0/G1 phase and low metabolism. The cells survive in a quiescent …

Background Advanced endometrial cancer often shows resistance to clinical chemotherapy
although potencies of anticancer drugs in vitro are promising. The disparity suggests that in …

Colon cancer (CC) is one of the most prevalent cancers in the world, and chemotherapy is
widely applied to combat it. However, chemotherapy drugs have severe side effects and …

Abstract Intercellular adhesion molecule (ICAM)-1, is a transmembrane glycoprotein of the
immunoglobulin (Ig)-like superfamily, consisting of five extracellular Ig‑like domains, a …

We introduce a novel microfluidic device to co-culture a blood vessel network and cell
tissues in an in vivo-like niche. Our “open-top” microfluidic device is composed of …

Ultrasmall gold nanoparticles (2 nm) easily penetrate the membranes of intestinal murine
epithelial cells (MODE‐K) and colorectal cancer cells (CT‐26). They are also taken up by 3D …