Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

Chronic kidney disease (CKD), defined as the presence of irreversible structural or
functional kidney damages, increases the risk of poor outcomes due to its association with …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but
also the leading cause of the end-stage renal disease (ESRD). The occurrence and …

The purpose of this study is to assess the safety and efficacy of finerenone therapy in type 2
diabetes mellitus (T2DM) patients with cardiovascular and chronic renal diseases. This meta …

Elevated blood pressure and hyperglycaemia frequently coexist and are both components of
metabolic syndrome. Enhanced cardiovascular risk is strongly associated with diabetes and …

Regulated Na+ transport in the distal nephron is of fundamental importance to fluid and
electrolyte homeostasis. Further upstream, Na+ is the principal driver of secondary active …

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause
of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs …

Background: Although diuretics are one of the most widely used drugs by nephrologists,
their antiproteinuric properties are not generally taken into consideration. Summary …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD)
worldwide. Its pathogenesis encompasses functional alterations involving elevated …