Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis

AS Farid, Y Horii - Lipids in health and disease, 2012 - Springer
The paraoxonase (PON) gene family includes three members, PON1, PON2 and PON3,
aligned in tandem on chromosome 7 in humans and on chromosome 6 in mice. All PON …

Anti-inflammatory, anti-oxidant and hepatoprotective effects of lactoferrin in rats

AS Farid, MA El Shemy, E Nafie… - Drug and chemical …, 2021 - Taylor & Francis
Carbon tetrachloride (CCl4) is a strong hepatotoxic agent. The ability of the anti-
inflammatory agent, lactoferrin (LF), to alleviate hepatic inflammation in a Wistar rat model …

Ameliorative effects of sildenafil against carbon tetrachloride induced hepatic fibrosis in rat model through downregulation of osteopontin gene expression

HE Nasr, AM Hegazy, NO El-Shaer, RS El-Shafey… - Scientific Reports, 2024 - nature.com
The liver carries out many essential tasks, such as synthesising cholesterol, controlling the
body's storage of glycogen, and detoxifying metabolites, in addition to performing, and …

Helminth infections and cardiovascular diseases: A role for the microbiota and Mϕs?

JD Lin, P Loke - Journal of Leukocyte Biology, 2021 - academic.oup.com
Cardiovascular diseases are rising in developing countries with increasing urbanization and
lifestyle changes and remains a major cause of death in the developed world. In this mini …

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats

AS Farid, AM Hegazy - Drug and Chemical Toxicology, 2020 - Taylor & Francis
Fluoroquinolones are some of the most common antibiotics used by clinicians all over the
world. Levofloxacin, a fluoroquinolone, is used therapeutically in numerous countries; …

Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naïve first episode psychosis

FF Brinholi, C Noto, M Maes, KL Bonifácio… - Schizophrenia …, 2015 - Elsevier
Background Activated immune-inflammatory pathways play an important role in the
pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated …

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

NO El-Shaer, AM Hegazy, MH Muhammad - Environmental Science and …, 2023 - Springer
Diabetes mellitus (DM) is a dysmetabolic disease characterized by chronic hyperglycemia.
In the developed countries, DM is the commonest life style disease that affects both old and …

Effects of Moringa oleifera Leaf Extract on Diabetes-Induced Alterations in Paraoxonase 1 and Catalase in Rats Analyzed through Progress Kinetic and Blind Docking

E Sierra-Campos, M Valdez-Solana… - Antioxidants, 2020 - mdpi.com
In our study, we aimed to evaluate the effects of Moringa oleifera leaves extract on rat
paraoxonase 1 (rPON1) and catalase (rCAT) activities in alloxan-induced diabetic rats. Our …

Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running

J Padilla, NT Jenkins, MD Roberts… - Experimental …, 2013 - Wiley Online Library
New Findings• What is the central question of this study? While it is well accepted that long‐
term physical inactivity is associated with an increased cardiovascular risk, the early effects …

[HTML][HTML] Vitexin and an HMG-Co A reductase inhibitor prevent the risks of atherosclerosis in high-fat atherogenic diet fed rats

X Lei, Y Yang - Journal of King Saud University-Science, 2020 - Elsevier
Vitexin, a flavone is known for its anti-oxidative and anti-inflammatory activities. The aim of
this study was to investigate the effect of vitexin in HFAD induced atherosclerosis risks in …