The frequent observation of organized lymphoid structures that resemble secondary
lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as …

Chronic inflammation drives the development of atherosclerosis, and details regarding the
involvement of different leukocyte subpopulations in the pathology of this disease have …

Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune
diseases. TLS present features of secondary lymphoid organs such as segregated T and B …

Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing
prevalence in western societies. Statins are widely applied in atherosclerosis therapy …

Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is
increasingly recognized that this intimal inflammation is paralleled over time by a distinct …

Inflammation is a fundamental process that protects organisms by removing or neutralizing
injurious agents. A key event in the inflammatory response is the localized recruitment of …

T cell cytokines are known to play a major role in determining protection and pathology in
infectious disease. It has recently become clear that IL-12 is a key inducer of the type 1 T cell …

Ectopic or tertiary lymphoid tissues develop at sites of inflammation or infection in peripheral,
non-lymphoid organs. These tissues are architecturally similar to conventional secondary …

Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …

Hallmarks of inflammation in various cardiovascular diseases, notably atherosclerosis, have
been observed for a long time. However, evidence for an (auto) antigen-driven process at …