Treg functional stability and its responsiveness to the microenvironment
Regulatory T cells (Tregs) prevent autoimmunity and tissue damage resulting from
excessive or unnecessary immune activation through their suppressive function. While their …
excessive or unnecessary immune activation through their suppressive function. While their …
DNA methylation as a future therapeutic and diagnostic target in rheumatoid arthritis
M Ciechomska, L Roszkowski, W Maslinski - Cells, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …
Effect of rhG-CSF combined with decitabine prophylaxis on relapse of patients with high-risk MRD-negative AML after HSCT: an open-label, multicenter, randomized …
L Gao, Y Zhang, S Wang, P Kong, Y Su, J Hu… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Relapse is a major cause of treatment failure after allogeneic hematopoietic stem-
cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim of …
cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim of …
Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
KA Helmin, L Morales-Nebreda… - The Journal of …, 2020 - Am Soc Clin Investig
Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature
during development, after which Tregs persist as a self-renewing population that regulates …
during development, after which Tregs persist as a self-renewing population that regulates …
Understanding the relevance of DNA methylation changes in immune differentiation and disease
Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …
Such diversity implies an intricate network of different cell types and interactions that are …
Applications of CRISPR epigenome editors in tumor immunology and autoimmunity
Over the past decade, CRISPR-Cas systems have become indispensable tools for genetic
engineering and have been used in clinical trials for various diseases. Beyond genome …
engineering and have been used in clinical trials for various diseases. Beyond genome …
[HTML][HTML] Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity
AJ Lam, DTS Lin, JK Gillies, P Uday, AM Pesenacker… - Cell Reports, 2021 - cell.com
Regulatory T cell (Treg) therapy is a promising curative approach for a variety of immune-
mediated conditions. CRISPR-based genome editing allows precise insertion of transgenes …
mediated conditions. CRISPR-based genome editing allows precise insertion of transgenes …
Epigenetic perspectives on systemic autoimmune disease
P Karagianni, AG Tzioufas - Journal of Autoimmunity, 2019 - Elsevier
Autoimmune diseases are characterized by increased reactivity of the immune system
towards self-antigens, causing tissue damage. Although their etiology remains largely …
towards self-antigens, causing tissue damage. Although their etiology remains largely …
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity
A Poli, S Abdul-Hamid, AE Zaurito… - Proceedings of the …, 2021 - National Acad Sciences
Regulatory T cells (Tregs) play fundamental roles in maintaining peripheral tolerance to
prevent autoimmunity and limit legitimate immune responses, a feature hijacked in tumor …
prevent autoimmunity and limit legitimate immune responses, a feature hijacked in tumor …
[HTML][HTML] Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation
JGC Peeters, S Silveria, M Ozdemir, S Ramachandran… - Cell Reports, 2024 - cell.com
The immunosuppressive function of regulatory T (Treg) cells is essential for maintaining
immune homeostasis. Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27) …
immune homeostasis. Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27) …