Pancreatic islet transplantation is a promising treatment option for individuals with type 1
diabetes; however, maintaining islet function after transplantation remains a large challenge …

Cell replacement therapy using stem-cell-derived insulin-producing β-like cells (sBCs) has
been proposed as a practical cure for patients with type one diabetes (T1D). sBCs can …

Background Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta
cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option …

To explore the effects immune‐isolating encapsulation has on the insulin secretion of
pancreatic islets and to improve our ability to quantitatively describe the glucose‐stimulated …

Prior to transplantation into individuals with type 1 diabetes, in vitro assays are used to
evaluate the quality, function and survival of isolated human islets. In addition to the …

Islet transplantation is a promising approach for treating patients with unstable T1DM.
However, it is confronted with numerous obstacles throughout the various stages of the …

The need for maintaining cell-spheroid viability and function within high-density cultures is
unmet for various clinical and experimental applications, including cell therapies. One …

Subcutaneous tissue is a promising site for islet transplantation, due to its large area and
accessibility, which allows minimally invasive procedures for transplantation, graft …

In the present study, we created a nanoscale platform that can deliver nutrients to pancreatic
islets in a controlled manner. Our platform consists of a mesoporous silica nanoparticle …

The transplantation of human pancreatic islets is a therapeutic possibility for a subset of type
1 diabetic patients who experience severe hypoglycemia. Pre-and post-transplantation loss …